BEGIN:VCALENDAR VERSION:2.0 PRODID:www.babraham.ac.uk X-WR-TIMEZONE:UTC X-PUBLISHED-TTL:P1W BEGIN:VTIMEZONE TZID:UTC X-LIC-LOCATION:UTC END:VTIMEZONE BEGIN:VEVENT UID:8366804473eeec30b90616c852b94f39 DTSTART;TZID=UTC:20210922T150000 SEQUENCE:0 TRANSP:OPAQUE DTEND;TZID=UTC:20210922T160000 SUMMARY:\"3D genome folding\, unfolding\, and refolding in the mammalian br ain\" CLASS:PUBLIC DESCRIPTION:_3D genome folding\, unfolding\, and refolding in the mammalian brain_\n\nJennifer Phillips-Cremins\n\nDepartment of Genetics - Perelman School of Medicine\n\nUniversity of Pennsylvania\, USA\n\n \n\nHosted by Stefan Schoenfelder\n\nJoin live here - https://zoom.us/j/97304071166\n\n_ The Cremins Lab focuses on higher-order genome folding and how\nclassic ep igenetic modifications work through long-range\, spatial\nmechanisms to go vern synaptic plasticity in healthy and diseased\nneural circuits. Much is already known regarding how transcription\nfactors work in the context of the linear genome to regulate brain\ndevelopment. Yet\, severe limitation s exist in our ability to engineer\nchromatin in neural circuits to correc t synaptic defects in vivo. At\nthe lab’s inception\, it remained unclea r whether and how genome\nfolding could functionally influence cell type-s pecific gene\nexpression. We have developed and applied new molecular and\ ncomputational technologies to discover that nested subTADs and\nlong-rang e loops undergo marked reconfiguration during neural lineage\ncommitment\, somatic cell reprogramming\, neuronal activity stimulation\,\nand in repe at expansion disorders. We demonstrated that loops induced\nby neural circ uit activation\, engineered through synthetic\narchitectural proteins\, an d miswired in fragile X syndrome were\ntightly connected to transcription\ , thus providing early insight into\nthe genome’s structure-function rel ationship. We are currently\nfocused on understanding how\, when\, and why 3D genome folding patterns\ncontribute to synaptic plasticity and dysfunc tion in neural circuits.\nAddressing this knowledge gap will provide an es sential foundation for\nour long-term goal to engineer the 3D genome to re verse pathologic\nsynaptic defects in debilitating neurological diseases._ \n\nJennifer Phillips-Cremins\, Ph.D. is an Associate Professor and Deans' \nFaculty Fellow in Engineering and Medicine at the University of\nPennsyl vania with primary appointments in the Departments of\nBioengineering and Genetics. Dr. Cremins obtained her Ph.D. in\nBiomedical Engineering from t he Georgia Institute of Technology in the\nlaboratory of Andres Garcia. Sh e then conducted a multi-disciplinary\npostdoc in the laboratories of Job Dekker and Victor Corces. Dr.\nCremins now runs the Chromatin Architecture and Systems Neurobiology\nlaboratory at UPenn. Her primary research inter ests lie in\nunderstanding the long-range chromatin architecture mechanism s that\ngovern neural specification and synaptic plasticity in healthy neu rons\nand how these epigenetic mechanisms go awry in neurodevelopmental an d\nneurodegenerative diseases. She has been selected as a 2014 New York\nS tem Cell Foundation Robertson Investigator\, a 2015 Albert P. Sloan\nFound ation Fellow\, a 2016 and 2018 Kavli Frontiers of Science Fellow\,\n2015 N IH Director's New Innovator Awardee\, 2020 NSF CAREER Awardee\,\nand a 202 0 CZI Neurodegenerative Disease Pairs Awardee.\n\n \n X-ALT-DESC;FMTTYPE=text/html:

3D genome folding\, unfolding\, and ref olding in the mammalian brain

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Jennifer Phillips-Cremins

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Department of Genetics - Perelman School of Medicine

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Univ ersity of Pennsylvania\, USA

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Hosted by Stefan Schoenfelder

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Join live here - https://zoom.us/j/97304071166

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T he Cremins Lab focuses on higher-order genome folding and how classic epig enetic modifications work through long-range\, spatial mechanisms to gover n synaptic plasticity in healthy and diseased neural circuits. Much is alr eady known regarding how transcription factors work in the context of the linear genome to regulate brain development. Yet\, severe limitations exis t in our ability to engineer chromatin in neural circuits to correct synap tic defects in vivo. At the lab’s inception\, it remained unclear whethe r and how genome folding could functionally influence cell type-specific g ene expression. We have developed and applied new molecular and computatio nal technologies to discover that nested subTADs and long-range loops unde rgo marked reconfiguration during neural lineage commitment\, somatic cell reprogramming\, neuronal activity stimulation\, and in repeat expansion d isorders. We demonstrated that loops induced by neural circuit activation\ , engineered through synthetic architectural proteins\, and miswired in fr agile X syndrome were tightly connected to transcription\, thus providing early insight into the genome’s structure-function relationship. We are currently focused on understanding how\, when\, and why 3D genome folding patterns contribute to synaptic plasticity and dysfunction in neural circu its. Addressing this knowledge gap will provide an essential foundation fo r our long-term goal to engineer the 3D genome to reverse pathologic synap tic defects in debilitating neurological diseases.

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Jennifer Phillips-Cremins\, Ph.D. is an Associate Professor and Deans' Faculty Fel low in Engineering and Medicine at the University of Pennsylvania with pri mary appointments in the Departments of Bioengineering and Genetics. Dr. C remins obtained her Ph.D. in Biomedical Engineering from the Georgia Insti tute of Technology in the laboratory of Andres Garcia. She then conducted a multi-disciplinary postdoc in the laboratories of Job Dekker and Victor Corces. Dr. Cremins now runs the Chromatin Architecture and Systems Neurob iology laboratory at UPenn. Her primary research interests lie in understa nding the long-range chromatin architecture mechanisms that govern neural specification and synaptic plasticity in healthy neurons and how these epi genetic mechanisms go awry in neurodevelopmental and neurodegenerative dis eases. She has been selected as a 2014 New York Stem Cell Foundation Rober tson Investigator\, a 2015 Albert P. Sloan Foundation Fellow\, a 2016 and 2018 Kavli Frontiers of Science Fellow\, 2015 NIH Director's New Innovator Awardee\, 2020 NSF CAREER Awardee\, and a 2020 CZI Neurodegenerative Dise ase Pairs Awardee.

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